Are we doing everything to meet their unique needs?

The Burden

Patients with Parkinson’s disease (PD) have 1 thing in
common: the burden they face is significant

  • PD Parkinson’s disease affects nearly 1 million people in the United States1,2
  • There are 60,000 new cases of PD diagnosed each year3
  • Parkinson’s disease is the fastest-growing neurological disorder4

MORE THAN MOTOR SYMPTOMS

Up to 83% of people with Parkinson’s disease experience nonmotor symptoms, such as depression, anxiety, and dementia.5

DISEASE PROGRESSION IS INEVITABLE

Despite ongoing research, the only treatment options available for PD focus on symptom management.6
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DIAGNOSIS IS DEVASTATING

As PD progresses, patients report declining quality of life.6
The Landscape of Needs in PD: Where Are We Now?
The Challenge

Current treatments do little to address the variable
nature of Parkinson’s disease5

FOR ALMOST 50 YEARS, CD/LD HAS BEEN THE GOLD STANDARD FOUNDATIONAL TREATMENT FOR PD2,7,8

However:
  • Many CD/LD patients report difficulty managing OFF time and side effects, including dyskinesia2,9
  • Newer formulations can be complicated and have low patient satisfaction6
  • As PD progresses, the therapeutic window narrows and motor complications (dyskinesia and OFF-time symptoms) occur6,10

DOSING STRATEGIES WITH CURRENT CD/LD TABLETS PUT PATIENTS AT RISK OF IMPRECISE DOSING

  • People with Parkinson’s  disease may bite, chew, or use methods other than pill splitters for partial doses of PD medications
  • Loss of tablet may occur during the pill-splitting process11
  • Dose inaccuracy may be a result of inaccurate splitting, leading to underdosing or overdosing11
  • There is limited evidence available on dose accuracy associated with splitting11
  • CD/LD=carbidopa/levodopa.
The Need

Patients with Parkinson’s disease need a better
way to personalize their treatment

Patients don’t always adhere to their daily prescribed amount of CD/LD

They may be splitting their CD/LD tablets to suit their unique needs11

When this happens, they put themselves at risk of taking too much or too little CD/LD11

People with PD are looking for a way to take control of their daily doses

AVION PHARMACEUTICALS IS COMMITTED TO HELPING THE PARKINSON’S DISEASE COMMUNITY FACE A BRIGHTER FUTURE

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Resources

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References: 1. Yang W, Hamilton JL, Kopil C, et al. Current and projected future economic burden of Parkinson’s disease in the U.S. NPJ Parkinsons Dis. 2020;6:15. doi:10.1038/s41531-020-0117-1. 2. Tanner CM. Exploring the clinical burden of OFF periods in Parkinson disease. Am J Manag Care. 2020;26(12 suppl):S255-S264. doi:10.37765/ajmc.2020.88517. 3. Parkinson’s Foundation. Statistics. Accessed August 17, 2021. www.parkinson.org/understanding-parkinsons/statistics. 4. Dorsey ER, Sherer T, Okun MS, Bloem BR. The emerging evidence of the Parkinson pandemic. J Parkinsons Dis. 2018;8(s1):S3-S8. doi:10.3233/JPD-181474. 5. Stoker TB, Greenland JC, eds. Parkinson’s Disease: Pathogenesis and Clinical Aspects. Codon Publications; 2018. 6. Jankovic J, Tan EK. Parkinson’s disease: etiopathogenesis and treatment. J Neurol Neurosurg Psychiatry. 2020;91(8):795-808. doi:10.1136/jnnp-2019-322338. 7. Olanow CW, Calabresi P, Obeso JA. Continuous dopaminergic stimulation as a treatment for Parkinson’s disease: current status and future opportunities. Mov Disord. 2020;35(10):1731-1744. doi:10.1002/mds.28215. 8. Tolosa E, Martí MJ, Valldeoriola F, Molinuevo JL. History of levodopa and dopamine agonists in Parkinson’s disease treatment. Neurology. 1998;50(6 suppl 6):S2-S10. doi:10.1212/wnl.50.6_suppl_6.s2. 9. Cabreira V, Soares-da-Silva P, Massano J. Contemporary options for the management of motor complications in Parkinson’s disease: updated clinical review. Drugs. 2019;79(6):593-608. doi:10.1007/s40265-019-01098-w. 10. Tambasco N, Romoli M, Calabresi P. Levodopa in Parkinson’s disease: current status and future developments. Curr Neuropharmacol. 2018;16(8):1239-1252. doi:10.2174/1570159X15666170510143821. 11. Chaudhri K, Kearney M, Di Tanna GL, Day RO, Rodgers A, Atkins ER. Does splitting tablet obtain the accurate dose?: a systematic review protocol. Medicine (Baltimore). 2019;98(42):e17189. doi:10.1097/MD.0000000000017189.